DMAA is a substance present in the composition of some dietary supplements, and is widely used as a pre-workout by people who practice physical activities, as this substance is capable of promoting fat loss and ensuring greater energy to perform exercise.
Despite being able to help the weight loss process, the distribution, marketing, dissemination and use of products containing DMAA has been suspended by ANVISA since 2013 due to the fact that it acts directly on the central nervous system and increases the risk of developing heart, liver and kidney diseases, due to example.
Furthermore, chronic use or high doses of this substance can cause dependence, which is why it is recommended that products containing DMAA in their composition are not consumed.
DMAA side effects
The side effects of DMAA are mainly associated with consumption in high doses, chronically and associated with other stimulant substances, such as alcohol or caffeine, for example.
The main mechanism of action of DMAA is vasoconstriction, which is why the adverse effects of frequent use of DMAA begin with a sudden increase in pressure, in addition to:
- Intense headache;
- Nausea;
- Agitation;
- Seizures;
- Cerebral hemorrhage or stroke;
- Renal insufficiency;
- Liver injuries;
- Cardiac changes;
- Dehydration.
Although DMAA was originally included in some dietary supplements, it is contraindicated for human use due to its serious health effects.
How DMAA works
The mechanism of action of DMAA is still widely debated, however it is believed that this substance acts as a stimulant of the central nervous system and leads to increased production of norepinephrine and dopamine. The greater amount of circulating noradrenaline stimulates the breakdown of fat molecules, providing extra energy for physical activity and helping the weight loss process.
Furthermore, the increase in the amount of circulating dopamine reduces the feeling of tiredness, increases focus during training and increases gas exchange, providing greater amounts of oxygen to the muscles.
However, due to its action on the nervous system, it is possible that frequent use and in high doses of this substance, especially when consumed in conjunction with other stimulant substances such as caffeine, for example, may result in dependence and liver failure and cardiac changes, for example.
