Trimebutine is an antispasmodic indicated for the treatment of irritable bowel syndrome, gastroesophageal reflux or gastrointestinal cramps, as it reduces spasms or contractions of the gastrointestinal tract, normalizing its movements.
This medicine can be found in the form of soft capsules containing 200 mg trimebutine malate, as a generic or under the trade names Irritratil, Trimeb or Digedrat, for example.
Trimebutine maleate can be used by adults or children over 12 years of age, and should only be used with the advice of a gastroenterologist, according to the condition being treated.

What is it for
Trimebutine is indicated for the treatment of:
- Irritable bowel syndrome;
- Pain when swallowing caused by gastroesophageal reflux;
- Non-ulcer poor digestion (dyspepsia);
- Pain or cramps caused by gastrointestinal spasms.
Furthermore, trimebutine maleate can be indicated for preparing diagnostic tests, such as X-rays or endoscopy of the gastrointestinal tract, as it promotes gastric emptying and prevents the appearance of nausea and vomiting.
Another indication for trimebutine is also preparation for a colonoscopy exam, as it reduces intestinal contractions, which can make the exam difficult.
The use of trimebutine maleate must be carried out with the recommendation of a gastroenterologist, with individualized doses according to the condition to be treated.
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How to drink
Trimebutin 200 mg capsules should be taken orally, with a glass of water or juice, preferably before meals.
The normally recommended dosage for adults is 1 capsule of trimebutine 200 mg, 2 to 3 times a day, according to medical advice.
The maximum dose per day should not exceed 600 mg, which corresponds to 3 capsules, and the treatment time must be determined by the doctor, varying according to the condition to be treated.
Possible side effects
The most common side effects of trimebutine are diarrhea, constipation, abdominal swelling, stomach pain, excessive urination, or redness of the skin.
Furthermore, although it is rarer, vomiting, dry mouth, headache, drowsiness or weakness may also occur.
Who shouldn’t use
Trimebutine should not be used by children under 12 years of age or by people who are allergic to trimebutine or any other component of the capsules.
During pregnancy, trimebutin should only be used with the advice of an obstetrician, and its use should be avoided in the first trimester of pregnancy.
Trimebutine during breastfeeding should also be used with medical advice, after evaluating the benefits of the treatment for the woman and potential risks for the baby.
Bibliography
- ANVISA. Trimeb (trimebutine maleate). 2023. Available at: <https://consultas.anvisa.gov.br/#/bulario/q/?nomeProduto=TRIMEB>. Accessed on 20 Jul 2023
- ANVISA. Digedrat (trimebutine maleate). 2021. Available at: <https://consultas.anvisa.gov.br/#/bulario/q/?nomeProduto=DIGEDRAT>. Accessed on 20 Jul 2023
- SAVIOLI, B. Trimebutine: a state-of-the-art review. Minerva Gastroenterol Dietol. 65. 3; 229-238, 2019
- BRENER, D. M.; LACY, B. E. Antispasmodics for Chronic Abdominal Pain: Analysis of North American Treatment Options. Am J Gastroenterol. 116. 8; 1587-1600, 2021
- ANVISA. Trimebutine maleate. 2022. Available at: <https://consultas.anvisa.gov.br/#/bulario/q/?nomeProduto=MALEATO%20DE%20TRIMEBUTINA>. Accessed on 20 Jul 2023
- ANVISA. Irritrail (trimebutine maleate). 2023. Available at: <https://consultas.anvisa.gov.br/#/bulario/q/?nomeProduto=IRRITRATIL>. Accessed on 20 Jul 2023
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