The collagen biostimulator is a substance that, when injected into the deepest layers of the dermis, is capable of stimulating collagen production, reducing signs of aging and increasing skin firmness.
Collagen biostimulation can be done with biocompatible substances, such as poly-L-lactic acid, calcium hydroxyapatite or polycaprolactone, which can be applied by the doctor to the face, neck, buttocks, abdomen, thighs, arms or hands, for example.
The application of the collagen biostimulator is carried out by the dermatologist, in the office, and may require 2 to 4 sessions, which varies depending on the type of biostimulator, and the results can be seen after 2 or 3 months of application.

10 benefits of collagen biostimulator
The main benefits of the collagen biostimulator are:
1. Rejuvenate the skin
The collagen biostimulator, when applied to the dermis, which is the deepest layer of the skin, stimulates the production of collagen, which as skin ages has its production reduced, leaving the skin with wrinkles, expression lines, sagging and with more aged appearance.
Thus, by stimulating collagen production, collagen bio-stimulators help to rejuvenate the skin, leaving the skin younger and healthier-looking. Check out other benefits of collagen for the body.
2. Reduce sagging skin
The collagen biostimulator, when applied to the face or neck, for example, helps restore skin firmness and reduce sagging, as by increasing collagen production in the area, it leaves the skin more elastic, with more volume and more defined. .
3. Reduce wrinkles and expression lines
By stimulating collagen production, the bio-stimulator helps reduce wrinkles and expression lines on the face, as well as improving the appearance of hands that become more wrinkled as the body ages naturally.
4. Soften the Chinese mustache
The collagen biostimulator may also have benefits for the Chinese mustache, which is an expression mark that develops around the mouth as the body ages naturally, becoming more evident when the person smiles.
These bio-stimulators can be used as one of the substances for facial harmonization, as when applied to the Chinese mustache they help to restore volume, leaving the skin smoother, softening the Chinese mustache. Find out what facial harmonization is and how it is done.
5. Improve skin texture
The collagen bio-stimulator helps improve the appearance of the skin, leaving it smoother, with a smoother texture, in addition to increasing the skin’s luminosity.
6. Reduce double chin
Double chins can appear as the body ages, and in this case, it is almost always caused by sagging skin on the neck.
In this way, the collagen bio-stimulator, by increasing elasticity and reducing sagging skin, can reduce double chin when applied to the neck.
7. Smooth cellulite
The collagen biostimulator can help soften cellulite, as it stimulates the natural production of collagen in the skin, combats sagging skin and leaves the skin thicker, with more volume and more uniformity, improving the appearance of skin with cellulite .
8. Reduce body sagging
The increase in collagen production stimulated by the bio-stimulating substance helps to make the skin firmer, which helps to reduce body sagging, especially on the face, arms, neck, buttocks, thighs or abdomen.
9. Improve the appearance of scars
The collagen biostimulator can help improve the appearance of scars, such as acne scars, for example.
This is because increased collagen production leaves the skin with more volume, firmer and more uniform.
10. Smooth hand wrinkles
Wrinkles on the hands are normal to appear as the body ages, however, the collagen biostimulator. When applied to the hands, it reduces sagging skin, fills in wrinkles, leaving hands looking younger.
How it works
The collagen biostimulator works by stimulating the skin’s natural production of collagen, elastin and hyaluronic acid, which are essential proteins for the skin’s cellular matrix, and which have their production reduced with the natural aging of the body.
In this way, by stimulating the production of these proteins, the bio-stimulating substance helps to restore skin elasticity, reduce sagging, increase hydration and promote skin rejuvenation.
How the application is made
The application of the collagen biostimulator is done by the dermatologist in the office, following a few steps:
- Apply a topical anestheticto avoid pain or discomfort when giving the injection;
- Prepare the biostimulatordiluting the biostimulator powder with serum and anesthetic;
- Clean the skin in the area to be treated with antiseptic solution;
- Apply the biostimulator in the deepest layers of the skin.
Generally, the biostimulator application time is around 30 minutes, but it may vary according to the region of the skin to be treated.
Places where it can be applied
The collagen biostimulator can be applied to the face, cheeks, Chinese mustache, neck, hands, arms, thighs, buttocks or abdomen, for example.
The application of the collagen biostimulator is carried out by the dermatologist, in the office, and depending on the type of substance applied, 2 to 4 sessions may be necessary, with an interval of 1 month between them.
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Types of collagen biostimulators
There are different types of biostimulating substances that are:
1. Poly-L-latic acid
Poly-L-lactic acid is an absorbable, semi-permanent collagen biostimulator that helps restore volume and gradually stimulate collagen production by the skin, and products containing this substance are known as Sculptra or Elleva.
The application of this bio-stimulator to the dermis, which is the deepest layer of the skin, can lead to an immediate increase in skin volume, which occurs due to swelling in the area applied, and which improves in around 2 to 3 days.
Poly-L-lactic acid then induces an inflammatory response in the skin, resulting in its breakdown into lactic acid, which while metabolized, stimulates the skin’s production of type 1 collagen. Check out the main functions of type 1 collagen.
The duration of this collagen bio-stimulator varies between 12 and 24 months, and generally requires between 3 and 4 applications.
2. Calcium hydroxyapatite
Calcium hydroxyapatite is another collagen biostimulator that works by stimulating the skin to produce more collagen, improving the appearance and texture of the skin, increasing volume immediately and gradually smoothing wrinkles and deep expression lines.
This bio-stimulator promotes the activation of fibroblasts in the skin, which are cells that produce collagen and elastin, and thus increases collagen production naturally.
The duration of this collagen bio-stimulator, known as Radiesse, lasts between 18 and 24 months, normally with 2 to 4 applications.
3. Polycaprolactone
Polycaprolactone is a bio-stimulator in the form of gel microspheres that increases the elasticity, volume and firmness of the skin immediately, in addition to stimulating collagen production in a uniform and gradual way, having a more prolonged and sustainable effect than poly-L-lactic acid.
The gel in this biostimulator has a high capacity to absorb water in the skin tissue, in addition to the microspheres being distributed evenly across the skin, leading to a marked production of type 1 collagen.
This biostimulator is known as Ellansé, lasting from 1 to 4 years, which varies according to the concentration of polycaprolactone in the product, normally requiring 1 application.
How long does the collagen biostimulator last?
The time that the collagen biostimulator lasts varies according to the type of substance applied, generally lasting 12 to 24 months, with maintenance applications generally required after 1 year.
Possible complications
Some complications from the application of collagen bio-stimulators are redness, swelling, pain or bruising, which improve within a few days.
Furthermore, although it is rarer, nodules or granulomas may form at the applied site, and are generally associated with errors in the application technique.
Therefore, the application of a collagen biostimulator must be carried out by a dermatologist experienced in aesthetic procedures.
Who shouldn’t do
The application of collagen biostimulators is contraindicated for people under 18 years of age, pregnant or breastfeeding women, or people with clotting problems.
Furthermore, it should also not be done on people who have active infections in the area of the skin to be applied, cold sores, sunburn, wounds in the healing process, psoriasis or dermatitis.
The application of collagen bio-stimulators should not be done on people who are allergic to any of the components of the formula.